The Denver Broncos open 2.5-point favorites at home to the Arizona Cardinals with an over/under at 36.5.
The Denver Broncos showed some life on offense for the first time all season last week and they will host an Arizona Cardinals team that has lost Kyler Murray for the season with a torn ACL. However, Denver also has its starting quarterback Russell Wilson in the concussion protocol and he may not be ready to go Sunday either.